Anti-platelet drugs play an important role in the treatment of patients with thrombotic diseases. The most commonly used anti-platelet drugs, namely, aspirin, ticlopidine, and clopidogrel, are effective in the prevention and treatment of cardiovascular diseases. Platelet activation plays a central role in haemostasis, thrombosis and useful in prevention of thromboembolic artery occlusions associated with cardiovascular diseases. This study was performed to examine the efficacy of ginger-juice in the animal models of thrombosis including mice model of pulmonary thromboembolism, arterio-venous shunt model in rats and coagulation parameters. Simultaneously we also studied the effect of ginger-juice on bleeding time, the most prevalent side effect of existing antiplatelet drugs. Intravenous administration of collagen-epinephrine in mice resulted into hind limb paralysis. Pre-treatment with ginger-juice (10 ml/kg) resulted into 25.56±5% protection against collagen and epinephrine induced pulmonary thromboembolism. At the same time bleeding time was also comparable to the aspirin. Standard compound aspirin also resulted into 28.60±2.5% protection; however bleeding time with aspirin was increased by approx 2 fold. The ex-vivo coagulation studies in mice demonstrated no significant affect among any of the coagulation parameters tested. However, administration of ginger-juice resulted in significant decrease in thrombus weight than in control rats (***p<0.001). Clopidogrel (10 mg/kg) treatment also significantly reduced the thrombus weight in comparison to control group (***p<0.001).
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